Two DOPs Deal With Operations, The 340B Program, And Drug Manufacturers’ Restrictions VytlOne recently organized an introductory Zoom meeting between the DOPs of two health systems we serve. Southwest Mississippi Regional Medical Center’s (SMRMC) Tiffany Poole earned her Doctorate of Pharmacy degree from the University of Mississippi in 2006. A VytlOne pharmacist since 2018, she … Read More
340B
What Is Your ROI Potential With An Optimized 340B Program?
Introducing VytlOne’s 340B Program ROI Calculator The 340B program has often been described, and with good reason, as a black box. There are dozens of factors impacting an individual hospital’s relative success or failure in generating positive returns from a program. VytlOne has optimized dozens of 340B programs — generating over $500 million in savings … Read More
Specialized Software Can Only Do So Much For 340B Programs
Why specialized software is essential for successful 340B programs As we’ve mentioned in several previous posts, many hospitals taking full advantage of 340B programs’ discounts save millions of dollars a year on prescription costs. However, 340B programs cover thousands of discounted drugs, and, for most eligible entities, thousands — if not tens of thousands — … Read More
Use Your Hospital’s Retail Pharmacy 340B Drug Savings To Build A Specialty Pharmacy
For 340B-eligible hospitals dealing with increasingly tight bottom lines (which essentially means all 340B-eligible hospitals), an in-house specialty pharmacy offers enormous savings and revenue potential. Some covered entities generate as much as 600% in specialty pharmacy revenue from 340B drugs as they do in traditional retail / outpatient or contract pharmacy 340B revenue. What is … Read More
6 Prescription-Reporting Errors To Avoid In 340B ESP
As we noted in a previous post, 340B ESP is nothing less than a brazen and (in our opinion) unlawful ploy by the drug manufacturers to evade the discounts they are legally obligated to offer eligible entities — by placing extraordinary, and unnecessary, reporting burdens on hospitals submitting claims for 340B savings. That said, until … Read More
340B ESP: Why It’s Wrong, And How Hospitals Can Deal With It
POST OUTLINE 1) Introduction / Overview 2) What is the 340B Drug Pricing Program? 3) A brief history of 340B ESP The reporting burdens 340B ESP place on covered entities. The real reason behind 340B ESP? 4) How we help eligible entities deal with 340B ESP Reporting your eligible prescriptions to 340B ESP. Tracking your … Read More
How Drug Manufacturer Restrictions And PBMs Undermine Hospitals’ 340B Savings And Outpatient-Pharmacy Margins
If you’re an eligible hospital with an existing 340B program, you know that your wholly-owned outpatient pharmacy is required to buy non-340B medications at Wholesale Acquisition Cost (WAC) — unless you’ve put it in an LLC, and registered it as a child site, or you’re a Critical Access Hospital, and exempt from the requirement. You’ve … Read More
Best Practices Every 340B Hospital Needs To Know
POST OUTLINE 1) Introduction Overview: Savings potential of a 340B program. 340B savings generated by VytlOne ($300M in 2025 alone. 2) Tips for maintaining 340B Program Compliance Why so many 340B eligible hospitals don’t have programs. 340B compliance checklist and additional resources. Definition of 340B Duplicate Discounts. 3) Patient eligibility, and who qualifies for 340B … Read More
What is 340B Double-Dipping, and How Can You Avoid It?
The 340B drug pricing program allows eligible providers to replenish prescriptions to eligible patients at significantly reduced pricing, and bill normal market rates for those prescriptions —helping the entities fill revenue gaps that are inherent to their business models. That said, the program does not allow eligible providers to take advantage of 340B discounts and … Read More
How, and Why, TPAs Misqualify 340B-Eligible Prescriptions
PLEASE NOTE: This article should not be construed as an attack on TPAs. VytlOne has managed 340B programs for dozens of hospitals, and we can’t imagine managing one without the services of a TPA. Is your health system 340B-eligible? We still frequently get this question, so: To qualify for 340B program eligibility, you need to … Read More










