Since 2019, VytlOne has supported the 340B programs of more than 100 health systems and health centers. We’ve published dozens of posts exploring 340B topics and trends — major, minor and developing. Recently, we were asked by a reader to produce a post offering our thoughts on, and predictions for, the program’s future. If there … Read More
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The Definitive 340B Compliance Checklist For 2025
Download Our Free Compliance Checklist PDF 340B health systems have been under increasing scrutiny and regulatory oversight in recent years. The Health Resources and Services Administration (HRSA) has indicated that it plans to increase the number and complexity of 340B program audits it conducts. Here’s how your health system can prepare every aspect of … Read More
Navigating 340B Program Changes in 2025
Maximizing pharmacy’s role in your hospital’s revenue cycle The 340B landscape continues to evolve rapidly, with ongoing manufacturer restrictions, new compliance hurdles, and increasing financial pressures on covered entities. The average 340B-eligible hospital loses a substantial amount of money due to drug manufacturer restrictions on the program. Recent estimates indicate that hospitals and clinics collectively … Read More
Which TPAs Are The Best At Optimizing 340B Savings And Revenue?
A covered entity’s guide to selecting TPAs for its 340B program TPAs play a critical role in any covered entity’s 340B program. It’s their job to match contract pharmacies’ prescription claims with patient data provided by the health systems they serve, to determine 340B eligibility — and generate entity savings. Without those matches, no prescriptions … Read More
Best Practices Every 340B Hospital Needs To Know
POST OUTLINE 1) Introduction Overview: Savings potential of a 340B program. 340B savings generated by VytlOne ($300M in 2025 alone. 2) Tips for maintaining 340B Program Compliance Why so many 340B eligible hospitals don’t have programs. 340B compliance checklist and additional resources. Definition of 340B Duplicate Discounts. 3) Patient eligibility, and who qualifies for 340B … Read More
How Can You Ensure 340B Compliance and Avoid Non-Compliance?
POST OUTLINE 1) Getting started with the 340B Program Are you 340B eligible? 340B Eligibility resource. 2) Maintaining 340B Program Compliance Why so many hospitals don’t take advantage of 340B eligibility. 340B compliance checklist and additional resources. 3) Medicaid Carve-in or Carve-out? 4) 340B Audits: Overview. Consequences of non-compliance. 5) What to do if your … Read More






