What Does The Future Hold For 340B, And How Can You Prepare?

November 11, 2025340B, 340B Software, Audit, Compliance, Covered Entities, Data, Data Mining, Drug Manufacturer Restrictions, News Updates, Overview, Patient Eligibility, Requirements

Since 2019, VytlOne has supported the 340B programs of more than 100 health systems and health centers. We’ve published dozens of posts exploring 340B topics and trends — major, minor and developing. Recently, we were asked by a reader to produce a post offering our thoughts on, and predictions for, the program’s future. If there … Read More

The Definitive 340B Compliance Checklist For 2025

July 22, 2025340B, Audit, Compliance, Covered Entities, Readmissions Reduction, Specialty Pharmacy, TPA / TPAs

Download Our Free Compliance Checklist PDF   340B health systems have been under increasing scrutiny and regulatory oversight in recent years. The Health Resources and Services Administration (HRSA) has indicated that it plans to increase the number and complexity of 340B program audits it conducts. Here’s how your health system can prepare every aspect of … Read More

Navigating 340B Program Changes in 2025

April 1, 2025340B, 340B ESP, Audit, Compliance, Contract Pharmacy, Covered Entities, Drug Manufacturer Restrictions, News Updates, Specialty Drugs, Specialty Pharmacy

Maximizing pharmacy’s role in your hospital’s revenue cycle The 340B landscape continues to evolve rapidly, with ongoing manufacturer restrictions, new compliance hurdles, and increasing financial pressures on covered entities. The average 340B-eligible hospital loses a substantial amount of money due to drug manufacturer restrictions on the program. Recent estimates indicate that hospitals and clinics collectively … Read More

Which TPAs Are The Best At Optimizing 340B Savings And Revenue?

December 8, 2022340B, Audit, Compliance, Contract Pharmacy, Covered Entities, TPA / TPAs

A covered entity’s guide to selecting TPAs for its 340B program TPAs play a critical role in any covered entity’s 340B program. It’s their job to match contract pharmacies’ prescription claims with patient data provided by the health systems they serve, to determine 340B eligibility — and generate entity savings. Without those matches, no prescriptions … Read More

Best Practices Every 340B Hospital Needs To Know

April 1, 2022340B, Audit, Bedside Prescription Delivery, Compliance, Contract Pharmacy, Covered Entities, Meds To Beds, Overview, Patient Eligibility, Requirements, Specialty Pharmacy, Specialty Pharmacy

POST OUTLINE 1) Introduction  Overview: Savings potential of a 340B program. 340B savings generated by VytlOne ($300M in 2025 alone. 2) Tips for maintaining 340B Program Compliance Why so many 340B eligible hospitals don’t have programs. 340B compliance checklist and additional resources. Definition of 340B Duplicate Discounts. 3) Patient eligibility, and who qualifies for 340B … Read More

How Can You Ensure 340B Compliance and Avoid Non-Compliance?

February 3, 2022340B, Audit, Compliance, Registration, Requirements

POST OUTLINE 1) Getting started with the 340B Program Are you 340B eligible? 340B Eligibility resource. 2) Maintaining 340B Program Compliance Why so many hospitals don’t take advantage of 340B eligibility. 340B compliance checklist and additional resources. 3) Medicaid Carve-in or Carve-out? 4) 340B Audits: Overview. Consequences of non-compliance. 5) What to do if your … Read More