Before we begin, we’re going to be honest with you. A significant component of VytlOne’s business is guiding 340B health systems through the process of building, accrediting, funding, launching and managing on-campus specialty pharmacies. Many times in this space, we’ve maintained that every 340B hospital should consider owning a specialty pharmacy. We’re currently in the … Read More
Specialty Drugs
So You Want To Build A 340B Specialty Pharmacy. How Hard Can It Be?
Fair Warning: If you ever dismissively ask that question (above) of someone who’s led the planning and launch of a 340B hospital’s specialty pharmacy, and did it with no outside support, there’s a good chance you’ll get punched. Yes, it’s that difficult. POST OUTLINE Why is it so hard to build a 340B specialty … Read More
How Recent 340B Changes Impact Specialty Pharmacies In 2025
The evolving legal and legislative landscape surrounding the 340B Drug Pricing Program has significant implications for hospitals’ specialty pharmacies. Here’s a breakdown of the new developments and their likely impacts: Recent 340B changes and their impact on specialty pharmacies 1. 340B contract pharmacy restrictions Drug manufacturers have increasingly restricted the use of contract pharmacies, especially … Read More
How To Use Your 340B Program As a Community Health Engine
We all know the 340B Drug Pricing Program was designed to enable eligible healthcare organizations to stretch scarce federal resources in serving underserved patients and expanding their missions in the community services. What we at VytlOne have learned in supporting the 340B programs of more than 100 health systems and health centers is that, properly … Read More
The Pharmacy Model That Restores Control To 340B Hospitals
How your health system can leverage visibility, your PBM and your pharmacies to achieve your financial and clinical goals. The systemic problem: Overview The U.S. prescription drug market is a textbook case of waste and inefficiency — one that, in recent years, has disproportionately benefited a handful powerful corporations at the expense of providers, … Read More
340B Outlook For 2024: Change. Change. And More Change.
POST OUTLINE 1) What we’ve learned. What it means for your 340B program. Overview of VytlOne 340B Team experience and successes Dealing with frequent, unexpected changes 2) Potential 340B developments for 2024 National legislation prospects State regulatory changes 3) Legislative & court updates Bill introduced into House Of Representatives Supreme Court overturns 340B restriction cuts … Read More
The Case for Onsite Specialty Pharmacies in 340B Hospitals
Why a Specialty Pharmacy? (Overview) As chronic illnesses become increasingly common in the United States, the number of specialty medications for managing these conditions has skyrocketed. According to a report by The American Hospital Association, the number of Americans with chronic medical conditions will grow by a projected 9% between 2020 and 2030, an increase … Read More
Best Practices For A 340B Hospital Looking To Build An Onsite Specialty Pharmacy
VytlOne recently gathered three of its corporate executives for an in-depth discussion of how an eligible health system can optimize revenues from its 340B program and its retail pharmacy, to help build and fund an onsite specialty pharmacy. Below is a lightly-edited transcript of that discussion. NOTE: If you’d prefer to watch the complete video … Read More
Partnering With Manufacturers To Overcome 340B Specialty Drug Restrictions
It’s no secret that the 340B Drug Pricing Program has been a lifeline for eligible health systems, enabling them to fill-in the massive revenue gaps inherent to the non-profit-hospital business model (and, in the process, support their mission of providing quality care to our nation’s most vulnerable patients) through access to discounted prescription refills. At … Read More
Your Hospital’s 340B Contract Pharmacy Network Is Not What It Should Be.
Based on our experience, it’s a claim we can make with 100% certainty. VytlOne has supported the 340B programs of more than 100 health systems and health centers since 2019. Altogether, we’ve generated nearly $1 billion in pharmacy-related savings for our clients. While the average 340B hospital’s revenues have decreased significantly since the 2020 advent … Read More










